In sickle cell anemia, erythrocyte membrane defects, red cell enzyme defects, thalassemia, and acquired hemolytic anemia result in stressed erythrocyte production as in hemorrhage, iron deficiency anemia and bone marrow transplantation, in which there may be a red cell hemolytic process, and the preceding PV infection can present with transient aplastic crisis (38), (39), (47).
In patients with hemolytic anemia, bone marrow examination is not required to establish the diagnosis of aplastic crisis.
Transient aplastic crisis occurs in the case of underlying chronic hemolytic anemia conditions, and chronic PRC anemia is presented by persistent infection in immunocompromised individuals.
Human serum "parvovirus": a specific cause of aplastic crisis in children with hereditary spherocytosis.
Parvovirus B19: a cause for aplastic crisis and hemophagocytic lymphohistiocytosis.