Phloroglucinol is an antispasmodic agent
that is used to treat acute pain related to functional disorders of the digestive tract and bile duct, [sup] but its mechanism of action is still unknown.
It is reported that surgical harvesting of the IMA leads to arterial spasm5,6; therefore, several antispasmodic agents
, such as papaverine7-9, calcium-channel blockers10 sodium nitroprusside11, nitroglycerine10,12 milrinone12,13, and phenoxibenzamine14 have been studied, compared, and used both topically and intraluminally to treat the perioperative spasm of the arterial conduits.
A 2012 meta-analysis of 23 RCTs with 2585 patients examined the effect of antispasmodic agents
, alone or in combination, to treat IBS.
7,8] Patients with mild and intermittent abdominal complaints, like our patient, can be treated with counselling, dietary recommendations (higher consumption of fibre, increased fluid intake) and antispasmodic agents
to support the intestinal functions.
decrease the intestinal smooth muscle activity, which might decrease abdominal discomfort if the pain is secondary to spasm of the intestinal smooth muscle.
Treatment includes advice on diet and exercise, information on stress management, and possible pharmacologic interventions--including antispasmodic agents
, antidepressants or anxiolytics, and fiber or laxatives, depending on symptoms.
Treatment includes offering advice on diet and exercise; providing information on stress management; and perhaps using pharmacologic interventions--including antispasmodic agents
, antidepressants or anxiolytics, and fiber or laxatives, depending on the patient's symptoms.
Ten different antispasmodic agents
were studied; in subgroup analyses, 5 of them--cimetropium/dicyclomine, peppermint oil, pinaverium, and trimebutine--were found to have statistically significant benefits.
may be useful in the treatment of IBS because they:
The antispasmodic agents
hyoscyamine and dicyclomine may give symptomatic relief of cramps and diarrhea, but there are insufficient data to make a recommendation about their use.