Among giardiasis patients, nitroimidazole treatment failure is often associated with failure of antiprotozoal drugs
in additional classes and with patient immunoglobulin deficiency.
If the cause is giardiasis, antiprotozoal drugs
will be prescribed.
Certain molecules isolated from natural sources represent a major breakthrough in the search for new antiprotozoal drugs
, since there is urgent need for a new era of innovative medicines (Rocha et at.
Natural products and the development of selective antiprotozoal drugs
Natural products and development of selective antiprotozoal drugs
In this context, the compounds (-) mammea A/BB (1) and 5,7-dihydroxy-8-(2-methylbutanoy1)-6-(3-methylbuty1)-4-phenyl-chroman-2-one (3) are potential candidates for further research to develop new antiprotozoal drugs
, considering their significant antileishmanial activity that may act in depolarization of the mitochondria] membrane potential cells, leading to death of the parasite.
Research on antiprotozoal drugs
of medicinal plant origin is a multidisciplinary task which involves researchers and students in the fields of botanics, phytochemistry, parasitology, pharmacology and medicine (Billo et al.
Natural products as sources of antiprotozoal drugs