The mechanism of action of topotecan as a topoisomerase I inhibitor differs from that of the antimetabolite
MTX often used for PCNSL.
There has been recent interest in the purine antimetabolite
mycophenolate mofetil as a disease-modifying agent in autoimmune diseases.
The chemotherapeutic agents selectively destroy the proliferating cancer cells, but dividing cells in other tissues and organs normally poisoned by such treatment (due to the high toxicity of the chemotherapeutic agents) are protected by the cold and the specificity of the organ receiving the antimetabolite
b/ Patients sometimes require additional management with an antimetabolite
MTX is an antineoplastic antimetabolite
with immunosuppressant actions.
32) Macrocytosis frequently occurs in those receiving antimetabolite
Methotrexate is an antimetabolite
used in the treatment of adult rheumatoid arthritis, severe psoriasis, and certain neoplastic diseases.
Azathioprine, a prodrug of 6-mercaptopurine (6-MP), acts as an antimetabolite
of purines after intracellular conversion by hypoxanthine guanine phosphoribosyl transferase into 6-thioinosine monophosphate (6-TEMP).
Sometimes a topical medication or antimetabolite
can be tried.
Certain conventional chemotherapies, such as the antimetabolite
gemcitabine, exert their anticancer activity at the S-phase of the cell cycle.
Eli Lilly's Alimta, a folate antimetabolite
, received approval as switch maintenance therapy in Europe in 2009 for patients with nonsquamous cell tumors and Tarceva also got the nod the following year.
Then the prodrug-activating enzyme produced in the cancer cell converts orally administered Toca FC, an investigational extended-release formulation of 5-fluorocytosine (5-FC), into a powerful antimetabolite
, 5-fluorouracil (5CaeFU), which kills the infected cancer cell and neighboring 5-FU sensitive tumor cells.
New guidelines have broadened the options for adjuvant chemotherapy in colon cancer patients who are at high risk of recurrence to include the alkylating agent oxaliplatin and the antimetabolite
In another large phase III trial conducted at Tokyo Medical University, chemotherapy with the oral antimetabolite
UFT after complete surgical resection of pathologic stage I NSCLC extended patient survival compared with surgery alone.
Then the prodrug-activating enzyme produced in the cancer cell is designed to activate orally administered Toca FC, an investigational extended-release formulation of 5-fluorocytosine (5-FC), into a powerful antimetabolite
, 5CaeFU, which kills the infected cancer cell and neighboring 5-FU sensitive tumor cells.