References in periodicals archive ?
Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor," Journal of Clinical Oncology, vol.
Kymriah uses the 4-1BB costimulatory domain in its chimeric antigen receptor to enhance cellular expansion and persistence.
8 million grant from the California Institute for Regenerative Medicine (CIRM) to fund a phase 1 chimeric antigen receptor (CAR)-T cell trial targeting an aggressive brain cancer called malignant glioma, which includes glioblastoma.
8 million grant from the California Institute for Regenerative Medicine (CIRM) to fund a phase 1 chimeric antigen receptor (CAR)T cell trial targeting an aggressive brain cancer called malignant glioma, which includes glioblastoma.
Axicabtagene ciloleucel (KTE-C19), Kite's lead product candidate, is an investigational chimeric antigen receptor T-cell therapy under development for the treatment of B-cell lymphomas and leukemias.
This facility is designed for cell therapy products that use viral vectors, such as chimeric antigen receptor T cell (CAR T cell) therapies, and will allow expansion of viral vector manufacturing to support gene therapy clinical and commercial programs and large scale production in 2,000L single-use bioreactors.
com)-- DelveInsight, the leading market research and consulting company has received immense positive feedback on its report PD-1 and PD-L1 inhibitors and Chimeric Antigen Receptor (CAR)-T cell Immunotherapy - Competitive Landscape, Pipeline and Market Analysis, 2015.
Chimeric antigen receptor (CAR) T cells are removed from the patient's blood and genetically altered in the lab to have specific antigen receptors (CARs) on their surface, which attach to proteins on the surface of cancer cells.
The modified T cells used in this study express an engineered fusion protein - called a chimeric antigen receptor - that combines the specificity of an antibody with the T cell signalling portions from two different proteins that stimulate the immune system to recognize ovarian cancer cells.
The study, published July 20, 2009, in Blood, shows that African-Americans with HIV who possess both a variation in the gene for the Duffy antigen receptor for chemokine (DARC) and leukopenia have slower HIV-to-AIDS progression rates than HIV-infected European-Americans with leukopenia.
BioTransplant says MEDI-507 is a humanized monoclonal antibody that binds specifically to the CD2 antigen receptor found on T cells and natural killer (NK) cells.
Allison was the first person to isolate the T-cell antigen receptor protein, a breakthrough which has been called one of the three most important findings in immunology in the last 20 years.
Yescarta is the first chimeric antigen receptor T cell therapy to be indicated for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including DLBCL not otherwise specified, primary mediastinal large B-cell lymphoma, high grade B-cell lymphoma and DLBCL arising from follicular lymphoma.
Cancer therapy company Moffitt Cancer Center reported on Monday the treatment of the first patient in the US with the new US Food and Drug Administration-approved Yescarta, a Chimeric Antigen Receptor T cell, or CAR-T, therapy, for patients with diffuse large B cell lymphoma, an aggressive form of non-Hodgkin lymphoma.
The first release today from Autolus announced the completion of the first-dose cohort of its Phase I/II study of AUTO2, its novel, dual-targeted Chimeric Antigen Receptor (CAR) in patients with relapsed/refractory melanoma.