Express researchers have shown that cancer cells expressing MHC Class II molecules can serve as potent vaccines for the treatment of cancer when the Ii (Invariant Chain) immunoregulatory protein is suppressed.
In general, the technique involves introducing a predetermined strength of antigen
(usually concentrate) into the skin and interpreting the wheal-and-flare response after 10 to 20 minutes.
Adjuvant: a substance that improves the immune response to an antigen
The various different antigen
sources used in the oral sensitization studies were either prepared or obtained from different suppliers.
Review of industry and academic stakeholder opinions involved in the vaccine antigen
e-mail security products use multiple scan engines to help provide comprehensive protection from viruses, spam and other security threats.
The Cancer Vac immunotherapy involves collecting blood from a patient, extracting a special type of white blood cell from the blood and then "loading" the isolated cells with a vaccine (comprising a mixture of a cancer antigen
and a sugar that is used to enhance uptake of the vaccine).
Mast cells sensitized in vitro with IgE respond to antigen
by degranulation and cytokine secretion.
To overcome this dilemma, the best possible antigens
would be needed to elicit the best possible immune response.
Serial dilution quantitative intradermal testing, also referred to as skin endpoint titration (SET), is a modified intradermal test that uses specific antigen
dilutions to establish the minimum amount of antigen
required to produce a positive skin test, also referred to as the endpoint.
Hoping to create individualized vaccines without requiring that the tumor have a known antigen
, Kufe's team in 1997 fused whole cancer cells with dendritic cells.
T-cells can only recognize antigen
when it is associated with a cell surface component, which they must see at the same time as the antigen
In preclinical studies, Select Vaccines has demonstrated proof-of-principle for expressing vaccine antigens
on Select VLPs with approximately 10 different antigens
The antibody levels measured by complement fixation (CF) against phase II Coxiella burnetii antigen
The tumor antigen
that is targeted in this project is a protein found on the surface of cancer cells.