The cardiotonic and antidysrhythmic effects of four triterpenoid derivatives, namely oleanolic acid (OA), ursolic acid (UA), and uvaol (UV), isolated from the leaves of African wild olive (Olea europaea, subsp.
On the basis of the vasodepressor, cardiotonic and antidysrhythmic effects of these compounds, it was concluded that OA and UV isolated from wild African olive leaves, or crude extract containing all components, can provide a cheap and accessible source of additive to conventional treatment of hypertension, complicated by stenocardia and cardiac failure.
Cardiotonic and antidysrhythmic
effects of oleanolic and ursolic acids, methyl maslinate and uvaol.
Amiodarone, while a highly effective antidysrhythmic
, has the potential to cause severe pulmonary toxicity, ranging from mild, reversible injury to pulmonary fibrosis.
A first subgroup of individuals was then selected from the above population on the basis of responses to the questionnaire, excluding those with any previous history of vascular disease or diabetes mellitus and those taking any cardioactive drugs (aspirin, [beta] blockers, diuretics, angiotensin-converting-enzyme inhibitors or angiotensin-2 blockers, [alpha] blockers, statins, calcium- or potassium-channel blockers, antidysrhythmic
drugs, or digoxin).