All blood samples in our study were collected in tubes containing potassium ethylenediaminetetraacetate (EDTA) as the anticoagulant agent
and they were analyzed in two hours following the sampling.
Furthermore, the use of different anticoagulant agents
in the blood tube also affect the platelet indices.
ARYx currently has four products in clinical development: an oral anti-arrhythmic agent for the treatment of atrial fibrillation, budiodarone (ATI-2042); an oral anticoagulant agent
for patients at risk for the formation of dangerous blood clots, tecarfarin (ATI-5923); a prokinetic agent for the treatment of various gastrointestinal disorders, ATI-7505; and, an agent for the treatment of schizophrenia and other psychiatric disorders, ATI-9242.
ARYx expects to complete an out-licensing agreement in the near term for the clinical development and commercialization of its oral anti-arrythmic agent, budiodarone, and, following that, entering into similar agreements for its two other late stage products, ATI-7505, for the treatment of various gastrointestinal disorders, and tecarfarin, an oral anticoagulant agent
ARYx announced on July 7, 2009 data from the Phase 2/3 clinical trial of its novel, oral anticoagulant, tecarfarin (formerly ATI-5923), compared to the leading anticoagulant agent
The most commonly known are antiplatelet and anticoagulant agents
, but some others can also disturb coagulation.
Severe mitral stenosis patients should not receive these novel anticoagulant agents
3 The newer oral anticoagulant agents
, Dabigatran etexilate (Direct thrombin inhibitor), Rivaroxaban and Apixaban (Factor Xa inhibitors), are also available for certain types thromboembolic conditions.
Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: focus on new anticoagulant agents
Since then, several new oral anticoagulant agents
have become available, including the direct thrombin inhibitor dabigatran (Pradaxa), and two factor Xa inhibitors--rivaroxaban (Xarelto) and apixaban (Eliquis)--which have been shown to be at least as effective as, if not more effective than, warfarin.
Oral Presentation Session: Anticoagulant Agents
Clinical Studies I