It can mimic ischaemic colitis (18), inflammatory bowel disease, sepsis or antibiotic-associated colitis
(10), all of which are common in the critically ill and it may coexist with other bowel pathology (10,14).
Patients receiving marketed fluoroquinolones have reported serious and occasionally fatal hypersensitivity and/or anaphylactic reactions, peripheral neuropathy, antibiotic-associated colitis
and tendon ruptures.
My experience with antibiotic-associated colitis
began in the early 1970s--although at that time the Clostridium difficile etiology was not known.
Clindamycin is contraindicated in patients with a history of regional enteritis, ulcerative colitis, antibiotic-associated colitis
, or hypersensitivity to preparations containing clindamycin or lincomycin.
CDAD is also implicated in the majority of cases of antibiotic-associated colitis
, which is one of the leading causes of morbidity and mortality among elderly debilitated patients.
The organism accounts for approximately 20 percent of cases of antibiotic-associated diarrhea and many of the cases of antibiotic-associated colitis