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2 /PRNewswire/ -- The many recent reports documenting the therapeutic efficacy of short interfering RNAs (siRNAs) in animal models of human disease may actually be describing non-specific therapeutic effects related to the ability of siRNA to activate an immune response, according to a paper in the September 2008 issue (Volume 19, Number 9) of 'Human Gene Therapy,' a peer-reviewed journal published by Mary Ann Liebert, Inc.
While SCS is not pursuing this objective, we do expect that this validation of our technology will generate new out-licensing opportunities for SCS with companies wishing to use the cells to engineer animal models of human disease.
In pre-clinical studies, MultiStem has been shown to be safe and effective in multiple animal models of human disease," said Dr.
RxGen's animal models of human disease and leading genomics and bioinformatics provide the company with a powerful platform for discovering and validating novel therapeutics.
It has also established animal models of human disease applying highly advanced technology such as genetic engineering as well as new in vivo evaluation systems using these animal models.
As worldwide demand for dedicated animal PET scanners increases, microPET provides a high performance PET solution for studies involving animal models of human disease and for pharmaceutical and radiotracer development," said Robert Nutt, president of Concorde Microsystems.
TTP889 has proven to be effective in preventing clot formation in several animal models of human disease, including stroke and pulmonary embolism, without any signs of the bleeding associated with traditional anticoagulants.
Researchers at TIGR, The Jackson Laboratories (TJL), Boston University (BU), Duke University (Duke), University of Pennsylvania (Penn) and Medical College of Wisconsin (MCW), have developed a broad-based response to this challenge in which they will develop a number of tools and techniques that will provide links between physiologically relevant animal models of human disease and the genes that are differentially expressed in those physiological models.
McKerlie is also associated with the Samuel Lunenfeld Research Institute, one of the world's leading academic centers in biomedical research, particularly in functional genomics and the development of genomic tools including a priority program that focuses on transgenic mouse and embryonic stem cell technologies to generate animal models of human disease.