This study also demonstrated that administration of a single dose of GRN163L at the time of animal inoculation
in the in vivo model of lung cancer metastasis resulted in decreased tumor burden at days 13, 20 and 27.
Isolation of this rickettsial agent from the patient's blood by animal inoculation
and by cell culture methods is ongoing.
In an in vivo model of lung cancer metastasis, in which tumor cells from an intravenous injection migrate to, attach and grow in lung tissue, a single dose of GRN163L at the time of animal inoculation
with A549-luc tumor cells resulted in significant reduction in tumor burden at days 13, 20 and 27 of tumor progression.
cell culture tests for the presence of certain cytocidal viruses (by inoculation of and blind passage in Vero, MRC-5, HeLa, RK, and A9 cells with observations for cytopathology and tests for hemadsorption and hemagglutination at the end of the culture period), and animal inoculation
tests for certain viruses (suckling and adult mice, guinea pigs, and embryonated hen eggs).
OTCBB:MDIR), a developer and marketer of patented needle-free jet injectors for human and animal inoculation
, today announced that on September 15th, 2004, the Japanese Ministry of Agriculture, Fishery and Forestry (MAFF) has endorsed its needle-free injection technology and has granted MIT's Japanese Distributor "Frontier International Co.