Following absorption, enalapril is hydrolyzed to enalaprilat, which is a more potent angiotensin converting enzyme inhibitor
than enalapril; enalaprilat is poorly absorbed when administered orally.
Most patients in the clinical trial supporting effectiveness, referred to as A-HeFT, received, in addition to BiDil or placebo, a loop diuretic, an angiotensin converting enzyme inhibitor
or an angiotensin II receptor blocker, and a beta blocker, and many also received a cardiac glycoside or an aldosterone antagonist.
In using PRINIVIL, consideration should be given to the fact that another angiotensin converting enzyme inhibitor
, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that PRINIVIL does not have a similar risk.
Acute hypotensive transfusion reaction during liver transplantation in a patient on angiotensin converting enzyme inhibitors
from low aminopeptidase P activity.
Among specific topics are anti-glaucoma carbonic anhydrase inhibitors as opthalmologic drugs, crystallographic studies of carbonic anydrases from fungal pathogens for structure-assisted drug development, sulfonylated matrix metalloproteinase inhibitors, Clostridium histolyticum collagenase inhibitors in the drug design, angiotensin converting enzyme inhibitors
, and inhibitors of histidinol dehydrogenases as antibacterial agents.
Mercaptopropanoyl) indoline-2-carboxylic acids and related compounds as potent angiotensin converting enzyme inhibitors
and antihypertensive agents.
Companies with key marketed angiotensin converting enzyme inhibitors
(ACEIs) and angiotensin II receptor antagonists (AIIRAs)-including Novartis, Aventis, Merck & Co.
Synthetic and fermentation-derived angiotensin converting enzyme inhibitors