is the swelling of deep dermis, subcutaneous, or submucosal tissue due to vascular leakage.
The study will measure the number of hereditary angioedema
attacks that subjects experience while receiving each treatment.
DX-2930 may be a viable prophylactic treatment option for hereditary angioedema
and other plasma kallikrein-mediated (PKM) diseases.
The drug, dubbed Cinryze, is the only drug in Europe with the indication for the prevention of hereditary angioedema
and was introduced on the US market several years ago, news agency Europa Press quoted the director of the Spanish unit of ViroPharma, Gilbert Credi, as saying today.
Findings demonstrated that the clinical trial, which assessed the safety and efficacy of the investigational drug Ruconest 50 U/kg for the treatment of acute attacks of angioedema
in patients with hereditary angioedema
(HAE), met the primary endpoint of time to beginning of symptom relief.
Rarely, a person may inherit the tendency to develop angioedema
, unrelated to an allergy.
Accordingly, the angioedema
was attributed to an idiopathic but possibly histaminergic cause.
The patient described her first episode of angioedema
at age two with recurrent episodes of angioedema
causing abdominal pain and hand swelling since then.
Patient charts were then excluded from further evaluation if complaints of itching, rash, urticaria, or angioedema
had been explained by physician-confirmed diagnoses.
Jimenez SN, Gomez VJ, Lopez TJ et al: Hereditary angioedema
in a patient with positive family history and low C4 is characteristic of hereditary angioedema
Acute and allergic angioedema
can be set off by a type of allergic reaction, for example a reaction to an insect sting, or by contact with certain foodstuffs, plants, drugs or pollens.
Conclusions: Bradykinin may be important in the causality of the erythema marginatum associated with hereditary angioedema
As many as 15 to 24 percent of people in the United States will experience urticaria (hives) or angioedema
(swelling) during their lifetime, caused by an allergic reaction, a common viral infection, or a serious illness, according to new medical guidelines developed by a joint task force of allergists, based in Englewood, Colorado.
today announced the launch of RUCONEST 50 IU/kg in the United States for the treatment of acute angioedema
attacks in adult and adolescent patients with hereditary angioedema