PHILADELPHIA -- Amniocentesis during the early second trimester did not substantially raise the risk of congenital foot anomalies in fetuses, compared with amnio done after 15 weeks of gestation.
The Alberta data set included 979 evaluable infants born following amniocentesis done from weeks 11 through 12 weeks 6 days, 2,515 infants born after amino done in weeks 13 through 14 weeks 6 days, and 962 infants born after amnio done in weeks 15 through 19 weeks 6 days.
4% in those who underwent amnio at 13-14 weeks 6 days, and 0.
The incidence of anomalies following amnio at weeks 11-13 was found to be significantly higher than when amnio was done in either of the other periods, said Dr.
Parents may prefer early second-trimester amnio over chorionic villi sampling (CVS) because CVS done at 13-15 weeks has a 1% risk of triggering a miscarriage, Dr.