In chicks, the lowering of blood aspartate aminotransferase
and alanine aminotransferase
activities was found to be specific for vitamin [B.
Biochemical response involved reverting abnormally high level of aminotransferase
to its normal range (3-35 IU/l).
1) Acute hepatitis A: elevated aminotransferase
levels with peak value above 500 U/L and negative serology test results for hepatitis B and hepatitis C infections; (2) Recent acute hepatitis A: elevated aminotransferase
levels with peak value below 500 U/L and either evolving S/CO (positive to borderline or negative) or resolving aminotransferase
values (normal AST level); (3) Resolved acute hepatitis A: aminotransferase
levels normal; (4) Indeterminate: elevated aminotransferase
levels below 500 U/L; neither evolving S/CO nor resolution of abnormal aminotransferase
In this study, parameters including alanin aminotransferase
(ALT), aspartate aminotransferase
(AST), alkaline phosphatase (ALP), total protein, malondialdehyde and fasting blood sugar (FBS) measured.
No pattern between years, sexes, or ages was apparent for plasma aspartate aminotransferase
, calcium, creatine kinase, lactate dehydrogenase, total protein, and triglycerides (Table 1).
It is "very important" to determine the frequency of "clinically significant elevations in aminotransferase
levels after gene transfer," the investigators wrote, adding that this will require a larger number of participants treated at the high-dose level.
Plasma alanine aminotransferase
and aspartate aminotransferase
activities were increased after TRI exposure in all mouse lines.
The values of serum alanine aminotransferase
(ALT) and aspartate aminotransferase
(AST), activator protein-1 m-RNA, [alpha]-smooth muscle actin, transforming growth factor-[beta], 14-hydroxynonenal and 8-oxo20deoxyguanosine, all markers of oxidative stress, liver compromise and stellate cell activation were significantly lower in the treatment group than the non treatment group.
Clinical studies have shown that a once-daily oral dose of REVOVIR not only reduces the amount of HBV DNA, but also normalises alanine aminotransferase
(ALT) levels in patients experiencing deterioration in liver function caused by chronic hepatitis B.
Methods: 17 patients with chronic hepatitis C and persistently elevated aminotransferase
levels were treated for 12 weeks with 3200 mg standardized ALE per day.
is a signal of liver toxicity.
McGoon from the Mayo Clinic, Rochester, Minnesota, and colleagues examined the incidence of increased serum aminotransferase
concentrations and the overall safety of ambrisentan in 36 patients who had previously discontinued other endothelin receptor antagonists because of increased serum aminotransferase
By day 4 of hospitalization, the patient's level of creatine phosphokinase had elevated to 146 266 U/L, the level of aspartate aminotransferase
was 3082 U/L, the level of alanine aminotransferase
was 1144 U/L, and the level of lactate dehydrogenase was 4687 U/L.
The drug has proven an effective inhibitor of virus replication and has indicated improvements in the increase of alanine aminotransferase
(ALT) and overall liver health.
Other endpoints observed in the study were a 57 percent increase in liver glycogen and no changes in muscle glycogen or in levels of plasma insulin or alanine aminotransferase