Mosquito-borne viruses causing diseases that affect public health in North Carolina included Eastern equine encephalitis virus (EEEV; Togaviridae family, Alphavirus
genus), La Crosse encephalitis virus (LACEV; Bunyaviridae family, Orthobunyavirus genus), SLEV, and WNV.
This is the first time the structure of an alphavirus
has been examined in this detail," Rossmann said.
Neuroprotective interventions targeting detrimental host immune responses protect mice from fatal alphavirus
Researchers say human trials will start within a year or two, and that the discoveries made could lead to vaccines for diseases stemming from other so-called alphaviruses
, such as various deadly strains of equine encephalitis, and the Ross River virus (which is an RNA alphavirus
endemic to Australia, Papua New Guinea, and other South Pacific islands).
Structure and replication of the alphavirus
A related alphavirus
, Fort Morgan virus, is a strain of BCRV (Pfeffer et al.
CHIKV is an enveloped, single-strand positive RNA Alphavirus
in the Togaviridae family (1).
The virus belongs to the family Togaviridae and the genus Alphavirus
He is focusing on three different species of alphavirus
to determine which genes to include in the polyvalent vaccine.
The family Togaviridae, genus Alphavirus
, includes several major mosquito-borne pathogens.
This, coupled with our experience in the production of alphavirus
replicons aligns well with the fundamental needs of this research, " said TriLink President and CEO, Dr.
Ross River Virus (RRV) is a mosquito-borne alphavirus
(Togaviridae) mainly indigenous to Australia and the Western Pacific region.
Chikungunya (CHIK) virus is an Arbo virus of the genus Alphavirus
and family Togaviridae (1,2).
The proteins then assembled themselves into harmless balls that resembled particles of Sindbis virus - a relative of chikungunya and a fellow member of the alphavirus
genus, which also includes a number of insect-borne viruses capable of causing dangerous encephalitis in humans.
Aventis Pasteur Limited (Toronto, Canada) has patented a vector comprising a first DNA sequence which is complementary to at least part of an alphavirus
RNA genome and having the complement of complete alphavirus
DNA genome replication regions, a second DNA sequence encoding a paramyxovirus protein, particularly a respiratory syncytial virus fusion (RSV F) protein or a RSV F protein fragment that generates antibodies that specifically react with RSV F protein, the first and second DNA sequences being under the transcriptional control of a promoter.