Similar treatment results have been reported for AHSCT and allogeneic transplantation
for Hodgkin diseases (44), indicating limited graft-vs-lymphoma effect.
The Food and Drug Administration has proposed regulatory strategies for processing hematopoietic progenitor cells derived from placental/umbilical cord blood, and the agency requires an Investigational New Drug application from those collecting and storing placental blood for human allogeneic transplantation
to continue examining and collecting global data on the practices, safety, quality, efficacy and epidemiology of allogeneic transplantation
and on ethical issues, including living donation, in order to update the Guiding Principles on Human Organ Transplantation;
A major reason for success of allogeneic transplantation
in myeloid and possible lymphoid malignancies was the suppressant effect of donor T lymphocytes and NK cells on the underlying malignancy.
Application of allogeneic transplantation
for the treatment of autoimmune disease has been limited by the risk of transplant-related complications including GVHD.
Today patients eligible for allogeneic transplantation
, but without a matched donor, have no treatment options.
The current concept of pathogenesis immune thyroiditis after allogeneic transplantation
is the transfer of a clone of donor lymphocytes with antithyroidal activity.
His current research interests include the investigation of non-myeloablative conditioning prior to allogeneic transplantation
and the use of allogeneic and autologous hematopoietic transplantation for hematologic malignancies and selected solid tumors.
Abstract # 1987: "Prophylaxis of Acute GvHD Using Stromal Cell Therapy: Preliminary Results After Administration of Single or Multiple Doses of Multistem in a Phase I Trial" Oral and Poster Abstracts: Clinical Allogeneic Transplantation
- Acute and Chronic GvHD, Immune Reconstitution: Poster I Saturday, December 10, 5:30 p.
Clinical Allogeneic Transplantation
- Acute and Chronic GVHD, Immune Reconstitution: Poster II Time: Sunday, December 8, 2013: 6:30 PM-8:30 PM Location: Hall G (Ernest N.
of mesenchymal stem cells between different individuals may also be possible as these cells appear to be immune privileged in that they are not necessarily rejected when implanted into unmatched recipients.
Burnett conceded, though, that given that both autologous and allogeneic transplantation
"have an antileukemic effect that is superior to that of chemotherapy, his statement may be an oversimplification.