The second step involved quaternization of tertiaryamino groups with an alkyl halide
However, there are other synthetic routes, mainly based on alkylation of N'-mono- or di-substituted hydrazine derivatives with alkyl halides
[4, 6-8] (Scheme 1, B), or introducing a protecting group into commercially available alkyl hydrazines [4, 7-10] (Scheme 1, C).
The Sr-mediated reaction produces high yields of both akylated and dialkylated adducts using alkyl halides
with easy handling.
5 of this source for the class of alkyl halides
, mercaptans, sulphides and disulphides.
Currently, most of the metal-mediated reactions involve allylation or propargylation, and more recently, secondary alkyl halides
Ferrocene is known to readily form charge transfer complexes (CTCs) with alkyl halides
, as evidenced by the appearance of a feature indicative of a charge transfer complex at ~310 nm; subsequently, upon irradiation, the complex dissociates into the ferrocenium ion, chloride ion, and alkyl radical (Fig.
IONIC REACTIONS: Nucleophilic Substitution and Elimination Reactions of Alkyl Halides