A confirmed case of agranulocytosis
after use of cocaine contaminated with levamisole.
Hematological side effects, including agranulocytosis
, non-thrombocytopenic purpura and thrombocytopenic purpura have been associated with beta-blocking agents, in general.
Up to three per cent of patients taking clozapine may develop neutropaenia and about one per cent develop agranulocytosis
However, azathioprine, (6,7) cyclophosphamide, (6) and methotrexate (12) have been used in cases of autoimmune hemolytic anemia, thrombocytopenia, and agranulocytosis
associated with Sjogren's syndrome.
The fear of agranulocytosis
is grossly exaggerated," Meltzer asserts.
Oxcarbazepine, the 10-ketoanalog of carbamazepine, is an effective anticonvulsant and shows little interaction with the cytochrome P450 system and minimal risk of agranulocytosis
Clozapine has the best evidence for treatment of patients with PD and psychosis, but patients on this agent must be monitored closely for agranulocytosis
The net proceeds from this financing will be used for general working capital purposes, executing the company's previously announced Phase III clinical trail of vilazodone for the treatment of depression, accelerating the integration of the newly acquired operations, development of genetic markers, and commercialization and market expansion for its genetic tests including its proprietary test for Long QT, Clozapine-Induced Agranulocytosis
and the warfarin response tests.
In 1975, side effects ultimately did occur: nine schizophrenic patients under dozapine treatment in Finland suddenly died from agranulocytosis
, a rare blood disease.
24-26) Hemolysis and agranulocytosis
can occur during the first few days of treatment; as mentioned, hemolysis can also occur in patients with low levels of G6PD.
Weekly white blood cell counts and weekly drug dispensing mandatory because of the risk of agranulocytosis
, which can be reversed if detected at an early stage.
For example, clozapine can cause sedation or anticholinergic effects, as well as increased agranulocytosis
and delirium in older patients.
Because of the risk of agranulocytosis
(dangerously low white blood count), clozapine must be monitored closely.
The first of these, clozapine (Clozaril[R]), has been shown to be more effective than other antipsychotics, although the possibility of severe side effects -- in particular, a condition called agranulocytosis
(loss of the white blood cells that fight infection) -- requires that patients be monitored with blood tests every one or two weeks.
In addition to many different side effects that patients may experience, the most serious complication is agranulocytosis
, a life-threatening disorder of the white blood cells.