LIDDS' single intratumoral injections of a NanoZolid formulated STING agonist
has been proven to achieve significant effects on tumour growth reduction and overall survival, the private company disclosed on Thursday.
Although GnRH agonist
initially binds and activates GnRH-receptors inducing a transient rise in gonadotropins, known as a flare-up, this is followed by a state of pituitary desensitization, resulting in a decrease in GnRH receptors and diminished response to GnRH stimulation.
The drug will also be the first dual TLR7and 8 agonist
administered directly into a tumor in a clinical setting.
The average age of PD patients in L-dopa and L-dopa and DA agonist
subgroups was older than that of de novo subgroup or HCs ( P < 0.
Our additional analyses adjusting for injecting drug use in the past month suggest that maintenance opioid agonist
therapy reduces the incidence of HCV infection in part by decreasing the frequency of injection, which will also lower the risk for acquiring HIV and other blood-borne pathogens," wrote Dr.
compared the flare-up versus the long GnRH agonist
regimen, and observed higher pregnancy and lower cancellation rates with the flare-up protocol (6).
Cytotoxicity interference is less of a concern for agonist
-mode assays than for antagonist-mode assays because agonists
that are cytotoxic at higher concentrations generate bell-shaped (inverted-U) concentration-response curves in the 460-nm channel.
This publication represents the first account of an in vivo active pepducin agonist
and demonstrates the promise for pepducin technology as a novel approach to target therapeutically important GPCRs.
WASHINGTON -- The Food and Drug Administration is conducting a safety study of several commonly used prostate cancer drugs in the aftermath of a preliminary review that suggests an increase in the risk of diabetes and certain cardiovascular diseases in men treated with gonadotropin-releasing hormone (GnRH) agonists
treatment in Parkinson's disease is associated with 2- to 3.
This study focused on generating agonist
ligand data for the alpha-2 AR which mediates the antiepileptic effects of the neurotransmitter norepinephrine in the hippocampus (2).
On the basis of preclinical evaluation in animal models of human conditions, one might expect a Delta agonist
to show effect in inflammatory pain, among other pain conditions.
Patients who took cabergoline, a dopamine agonist
(a drug that mimics the effects of the dopamine in the brain) used to control movement problems caused by Parkinson's, were compared to others who took the dopamine agonists
pergolide and pramipexole, and to a control group who did not receive a dopamine agonist
Under the terms of the agreement, Merck will receive worldwide exclusive rights to a number of Idera's agonist
compounds targeting TLR 7, 8 and 9 for use in combination with Merck's therapeutic and prophylactic vaccines under development for oncology, infectious diseases and Alzheimer's disease.
Chochinov and colleagues at Sunnybrook and Women's College Health Sciences Centre, Toronto, culled the medical literature for studies published between 1966 and 2001 that compared ephedrine with an [alpha]-1 agonist
for the treatment or prevention of hypotension due to neuraxial blockade during elective C-sections among women carrying full-term pregnancies.