agonist


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Related to agonist: Agonist muscle, Dopamine agonist
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  • noun

Synonyms for agonist

the principal character in a work of fiction

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someone involved in a contest or battle (as in an agon)

a muscle that contracts while another relaxes

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(biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction

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References in periodicals archive ?
In addition, ex vivo treatment with Lycera's RORgamma agonist compounds has been shown to enhance the therapeutic benefit of adoptive T-cell therapy by improving both immune cell persistence and activation.
Our additional analyses adjusting for injecting drug use in the past month suggest that maintenance opioid agonist therapy reduces the incidence of HCV infection in part by decreasing the frequency of injection, which will also lower the risk for acquiring HIV and other blood-borne pathogens," wrote Dr.
These StaRs and structures can be used to select and design compounds with specific pharmacologies, such as inverse agonist, partial agonist or full agonist, based on their ability to bind differentially to the agonist and antagonist StaRs.
compared the flare-up versus the long GnRH agonist regimen, and observed higher pregnancy and lower cancellation rates with the flare-up protocol (6).
Cytotoxicity interference is less of a concern for agonist-mode assays than for antagonist-mode assays because agonists that are cytotoxic at higher concentrations generate bell-shaped (inverted-U) concentration-response curves in the 460-nm channel.
Adolor and Pfizer Inc (NYSE:PFE) are collaborating on the worldwide development and commercialization of two novel Delta opioid agonist compounds, ADL5859 and ADL5747, for the treatment of pain.
Furthermore, we look forward to working closely with Merck's world-class chemists to expand our portfolio of novel TLR 7 and TLR 8 agonist compounds.
In 8 of the 13 randomized trials, umbilical artery pH levels were significantly better in the [alpha]-1 agonist groups, compared with the ephedrine groups.
Pretreating the rats with a dopaminereceptor antagonist, which blocks the receptors, prevented the agonist from working its magic, they report.
The report compared the use of the newer anti-inflammatory drugs with the more conventional asthma drugs, such as theophylline and the newer bronchodilators known as beta-2 agonists.
However, PPAR-gamma agonists have been able to maintain patient share among recently treated patients because physicians are less likely to switch a patient who is responding well to a PPAR-gamma agonist away from that drug, unless the patient has specific risk factors or has experienced side effects.
CHIAGO - Only 31% of patients with type 2 diabetes who were placed on a glucagonlike peptide-1 agonist persisted on the medication for at least 6 months in a very large national retrospective cohort study.
At lower concentrations, the difference between GCA and TEF approaches depended on the efficacy of the partial agonist.
This study is focused on generating functional agonist data for alpha-2 AR which mediates the antiepileptic effects of the endogenous neurotransmitter norepinephrine (NE) in the hippocampus (2).
A critical appraisal of the clinical results of advanced GLP-1 receptor agonist projects and products is provided.