The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers.
Expression of p75 neurotrophin receptor in desmoplastic trichoepithelioma, infiltrative basal cell carcinoma, and microcystic adnexal carcinoma.
Vulvar syringomas with deep extension: a potential histopathologic mimic of microcystic adnexal carcinoma.
Plaque-typesyringoma: two cases misdiagnosed as microcystic adnexal carcinoma.
CMBC-1 Ductal, NOS type 1 0 CMBC-2 Ductal, NOS type 1 0 CMBC-3 Ductal, NOS type 0 0 CMBC-4 Ductal, NOS type 0 0 CMBC-5 Ductal, NOS type 0 0 CMBC-6 Ductal, basal phenotype 0 0 CMBC-7 Ductal, NOS type 1 0 CMBC-8 Ductal, NOS type 0 0 CMBC-9 Ductal, NOS type 0 0 CMBC-10 Ductal, NOS type 1 1 CMBC-11 Ductal, NOS type 0 0 CBMC-12 Ductal, NOS type 0 0 SGC-1 Eccrine carcinoma 1 1 SGC-2 Eccrine carcinoma, ex 0 0 spiradenocylindroma SGC-3 Porocarcinoma 1 1 SGC-4 Porocarcinoma 1 1 SGC-5 Microcystic adnexal carcinoma 1 1 SGC-6 Eccrine carcinoma 1 1 SGC-7 Porocarcinoma 1 1 SGC-8 Microcystic adnexal carcinoma 1 1 SGC-9 Microcystic adnexal carcinoma 1 1 SGC-10 Eccrine carcinoma 1 1 SGC-11 Eccrine carcinoma, ex 0 1 spiradenocylindroma Case ID [CK5.
Finally, Liang et al (23) investigated the use of podoplanin to differentiate metastases to skin from various organ sites, including the breast, from primary skin adnexal carcinomas.
of the skin, I: eccrine carcinomas.
Various immunohistochemical markers have been studied to help distinguish desmoplastic trichoepitheliomas (DTE), infiltrating or morpheaform BCCs, and microcystic adnexal carcinomas
, including CD23, CD5, CD10, CD34, CK20, CK15, stromelysin-3, BCL2, AR, pleckstrin homology-like domain, family A, member 1 protein (PHLDA1), p75 neurotrophin receptor (p75NTR), fibroblast activation protein (FAP), Ber-EP4, p63, and others (34-48) (Table 2).
When making a diagnosis of hidradenocarcinoma, the differential diagnosis includes several other tumors, such as lipomas, hemangiomas, lymphangiomas, squamous cell carcinomas, basal cell carcinomas, malignant melanoma, other malignant adnexal carcinomas
, and metastatic tumors to the skin.
65) In addition, most primary adnexal carcinomas
and their metastases express p63, whereas visceral adenocarcinomas and their cutaneous metastases do not make this stain a useful adjunct to distinguish primary cutaneous adnexal carcinomas
from metastatic visceral adenocarcinomas.