When is a diagnosis of sclerosing adenosis
acceptable at core biopsy?
2-10) Pathologic examination of a radial scar often reveals a diverse array of pathologic findings including typical epithelial hyperplasia, sclerosing adenosis
, papillomatosis, atypical epithelial hyperplasia, ductal carcinoma in situ (DCIS), and early stage invasive carcinomas.
Similarly, basal cell markers may show absent or focal/weak staining in benign mimics of cancer, such as HGPIN, glandular atrophy, adenosis
, or posthypertrophic hyperplasia.
1 Calcifications Nonflorid Low LCIS and benign ducts 2 Calcifications Florid and Intermediate LCIS and nonflorid benign ducts 3 Calcifications Nonflorid Intermediate LCIS and sclerosing adenosis
4 Calcifications Florid Intermediate LCIS 5 Calcifications Nonflorid Low LCIS 6a Nodule Nonflorid Intermediate Not present Radiographic Excisional Biopsy Case Target Pathology No.
Vaginal epithelial changes in young women enrolled in the National Cooperative Diethylstilbestrol Adenosis
Myoepithelial cells are present in the normal mammary duct system and are often prominent in benign lesions, such as usual ductal hyperplasia, sclerosing adenosis
, and intraductal papilloma.
9) There are 4 subtypes of florid papillomatosis, which include the sclerosing papillomatosis, papilloma, adenosis
, and mixed proliferation patterns.
The controls were younger, consisting of patients exhibiting fibrosis and adenosis
with a mean age of 36 [+ or -] 7.
A challenging differential diagnostic situation is the extension of a DCIS lesion into adjacent benign structures or foci of sclerosing adenosis
, giving the morphologic impression of microinvasion.
Unfortunately, lack of basal cell markers and positive AMACR staining can occur in small foci of benign mimickers of PCa, including adenosis
(atypical adenomatous hyperplasia) and partial atrophy, and AMACR is positive in only about 80% of limited PCa foci on needle biopsy.
The opposite breast biopsy showed a radial sclerosing lesion in a background of extensive, proliferative, fibrocystic changes including florid sclerosing adenosis
and the usual ductal hyperplasia with microcalcifications.
is also referred to as atypical adenomatous hyperplasia, atypical adenosis
, small acinar atypical hyperplasia, and small gland hyperplasia.
Negative basal cell marking in some glands is a well-recognized phenomenon in benign mimickers of adenocarcinoma, especially the mimickers PTAT and adenosis
It is likely that, with immunostaining for basal cells, many of the original Gleason 1 + 1 = 2 PCa would today be regarded as adenosis
(atypical adenomatous hyperplasia), that is, a benign lesion.
3) It is well recognized that the cytologic alterations can be misdiagnosed as apocrine ductal carcinoma in situ (apocrine DCIS) if pathologists do not apply diagnostic criteria for atypical apocrine adenosis