After sequence analysis, all exons except exon 3 did not show any pathogenic variations while the electropherogram analysis of exon 3 indicated the insertion of one adenine nucleotide
between codons 335-336 in a homozygous manner (Figure 2A).
Chemical and physical methods that involve deproteinization to measure intracellular concentrations also release bound forms of adenine nucleotides
(Harris et al.
Hitherto, the putative components include the voltage-dependent anion channel (VDAC) or porin, localized in the OMM; the adenine nucleotide
translocator (ANT) in the IMM; the peripheral benzodiazepine receptor and the Bcl-2 family proteins; the hexokinase boundtoporin; the cyclophilin-D(Cyp-D), a regulatory element in the matrix; glycogen synthase kinase-3b (GSK-3b); and cytochrome c [121-123].
Elevated plasma adenine nucleotide
levels in chronic renal failure and their possible significance.
Relationship between oxidative phosphorylation and adenine nucleotide
translocase activity of two populations of cardiac mitochondria and mechanical recovery of ischemic hearts following reperfusion.
The researchers speculate that because the heart cells also produce ANT2, another form of the adenine nucleotide
translocator protein, enough ATP gets out to prevent enlargement of the mitochondria.
31) There are numerous clinical and laboratory studies showing that supplementing with ribose will enhance the recovery of adenine nucleotide
pools as well as enhancing diastolic function in heart pathology.
2008) Leishmania mexicana amazonensis: plasma membrane adenine nucleotide
translocator and chemotaxis.
synthesis in exercising and endurance-trained skeletal muscle.
Typically, phosphagen concentrations are higher than adenine nucleotide
concentrations (Beis and Newsholme, 1975; Meyer et al.
Of renewed interest is the inability of the heart to replenish rapidly its adenine nucleotide
pool once it has been diminished during a brief period of regional ischemia [2, 9].
D-ribose has been shown to increase energy production in the heart and skeletal muscle by providing a substrate for the synthesis of adenine nucleotide
, which is, in some circumstances, a rate-limiting factor for the production of ATP.
Platelets of patients with ET are also abnormal in plasma membrane and adenine nucleotide
The heart's ability to resynthesize ATP is then limited by the supply of D-ribose, which is a necessary component of the adenine nucleotide
Booth and colleagues suggest that the delayed fatigue may be due to loss of adenine nucleotides
needed to make ATP that occurs during the adenylate kinase reaction.