The Multi-Kinase Inhibitor Midostaurin (M) Prolongs Survival Compared with Placebo (P) in Combination with Daunorubicin (D)/Cytarabine (C) Induction (ind), High-Dose C Consolidation (consol), and As Maintenance (maint) Therapy in Newly Diagnosed Acute Myeloid Leukemia
(AML) Patients (pts) Age 18-60 with FLT3 Mutations (muts): An International Prospective Randomized (rand) P-Controlled Double-Blind Trial (CALGB 10603/RATIFY[Alliance]).
Another newly published market research titledRelapsed Acute Myeloid Leukemia
- Pipeline Review, H2 2015 provides comprehensive information on the therapeutic development for Relapsed Acute Myeloid Leukemia
, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
The psuedo-Chediak-Higashi anomaly: an unusual staining pattern in an Indian child with acute myeloid leukemia
Now we know that patients can receive appropriate therapy without increased risk of developing acute myeloid leukemia
and myelodysplastic syndrome in the first three years.
The distinct morphologic features of marrow blasts, mentioned above, or a suggestive immunophenotype raises suspicion of acute myeloid leukemia
with t(8; 21) or inv(16).
He and his coinvestigators used data from the Surveillance, Epidemiology, and End Results 9 (SEER 9) cancer registry to establish a prospective cohort for which complete treatment and acute myeloid leukemia
incidence data were available.
About Acute Myeloid Leukemia Acute myeloid leukemia
(AML) is a cancer that impacts the blood and bone marrow and is most commonly experienced in older adults.
The study led by physician-scientists at the University of California, San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center validates certain activating mutations in the FLT3 gene as targets for acute myeloid leukemia
therapy-a critically important finding for developing drugs.
Studies have shown that FLT3 ITD and normal cytology are strongly associated with cup-like morphology in acute myeloid leukemia
For example, a new diagnosis of acute myeloid leukemia
lacking expression of CD34 and HLA-DR raises the possibility of an acute promyelocytic leukemia and would prompt careful morphologic review, consideration of cytogenetic fluorescence in situ hybridization (FISH) for the t(15;17); PML-RARA, and clinical evaluation of the patient for evidence of disseminated intravascular coagulation.
Nevertheless, physician Simone Boehrer of the Gustave-Roussy Institute in Villejuif, France, and her colleagues tested erlotinib in a lab dish on bone marrow cells taken from 10 patients with either acute myeloid leukemia
or a precancerous blood disorder called myelodysplastic syndrome.
Mylotarg is a calicheamicin-conjugated humanized anti-CD33 monoclonal antibody indicated for the treatment of acute myeloid leukemia
SAN ANTONIO -- Secondary acute myeloid leukemia
and myelodysplastic syndrome is high following dose-intensified doxorubicin /cyclophosphamide for breast cancer, said Dr.
We conducted a retrospective review of pathology files and hospital records and identified three unusual presentations of granulocytic sarcoma associated with acute myeloid leukemia
(AML) of the head and neck.
Korte and colleagues from the University of North Carolina at Chapel Hill compared published epidemiological data to their own risk assessment predictions to determine the proportion of all types of leukemia and acute myeloid leukemia
(AML) attributable to benzene in cigarette smoke [EHP 108:333-339].