Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia
of Down syndrome.
The marrow findings, in conjunction with clinical findings, raised a few differential diagnostic possibilities: primary myelofibrosis, acute megakaryoblastic leukemia
, or acute panmyelosis with myelofibrosis.
Acute megakaryoblastic leukemia
can be more difficult to distinguish from pure erythroid leukemia.
5) Occasionally, however, TMD has preceded acute megakaryoblastic leukemia
(AML-M7) after a period of remission lasting several months to years.
1,2) A rare form of childhood leukemia, acute megakaryoblastic leukemia
, is approximately 500 times more common in children with DS than in healthy children.