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This means the patented subject matter covers screens using any ubiquitin activating enzyme, any ubiquitin conjugating enzyme or any ligase as the drug target.
MLN4924 data build on the growing body of evidence supporting the importance of the Millennium-discovered Nedd8 Activating Enzyme (NAE) in tumor growth and survival.
The System produces a second-generation surgical sealant which harvests from a patient's plasma the two interactive protein component solutions of a fibrin sealant: (1) the wound healing proteins of fibrinogen, fibronectin, Factor VIII, von Willebrands Factor and Factor XIII and (2) the activating enzyme thrombin.
This means the patented subject matter covers screens using any ubiquitin activating enzyme (E1), any ubiquitin conjugating enzyme (E2) or any ligase (E3) as the drug target.
3537479, for the CryoSeal FS System which utilizes an automated medical device and single-use sterile disposable to harvest and concentrate wound healing proteins such as fibrinogen and fibronectin and the activating enzyme thrombin from autologous (patient's own) plasma in about one hour.
The sprouting process involves soaking the nuts for 24 hours, unlocking the true nutritional potential of the almonds by activating enzymes and removing indigestible "anti-nutrients".
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