1,3,10) The relative rarity of ductal cancer and its frequent admixture with acinar adenocarcinoma further complicates its histological recognition.
1), while the remaining 33% (6/18) showed acinar adenocarcinoma.
Microscopic examination of the resection specimen revealed prostatic acinar adenocarcinoma, which was unilateral, multifocal, and predominantly peripheral.
To our knowledge, this is the first reported case of prostatic acinar adenocarcinoma with micropapillary architecture.
One of the most common benign mimickers of prostatic acinar adenocarcinoma
in prostate biopsies is partial atrophy (PTAT), and this differential diagnosis is a frequent reason for consultations.
Infiltrating cribriform acinar adenocarcinoma
(Gleason patterns 4 or 5, depending on whether comedonecrosis is present) closely mimics cribriform IDC-P.
16-18) Features favoring benign atrophy rather than atrophic-pattern adenocarcinoma include lack of infiltrative pattern of atrophic glands between larger benign glands, lack of coexisting usual acinar adenocarcinoma
with a moderate amount of cytoplasm, and lack of diffuse, significant cytologic atypia in the glands of concern.
The single cytology pleural fluid specimen was an acinar adenocarcinoma
, and the 2 cases of metastasis to lymph nodes (patients 18 and 19) showed mixed subtype adenocarcinoma with papillary, and a small solid pattern in one of the nodes and an acinar pattern in the other.
Differentiation of adenoid cystic/basal cell carcinoma from basal cell hyperplasia and cribriform pattern of acinar adenocarcinoma
may be difficult.
Papillary ductal (endometrioid) adenocarcinoma of the prostate and acinar adenocarcinoma
may present as exophytic papillary proliferation into the prostatic urethra and, therefore, could potentially be seen in urine samples.