For Appendix C, skip the acetylcholinesterase
Sieboldine A, a novel tetracyclic alkaloid from Lycopodium sieboldii, inhibiting acetylcholinesterase
Prenatal exposure to the acetylcholinesterase
inhibitor methanesulfonyl fluoride alters forebrain morphology and gene expression.
L-Phenylalanine effect on rat brain acetylcholinesterase
Vobasinyl-iboga bisindole alkaloids, potent acetylcholinesterase
inhibitors from Tabernaemontana divaricata root.
By blocking the operation of the enzyme acetylcholinesterase
, the activity of the neurotransmitter can be raised to compensate for this loss.
The original APP inhibitory activity should give us disease modification, while acetylcholinesterase
inhibition should lead to better short term improvements in cognition and neuro-regeneration could lead to a halt in the cognitive decline.
The insecticide would work by interfering with an enzyme found in the nervous systems of mosquitoes and many other organisms, called acetylcholinesterase
The influence of aging and of L-alpha-glycerylphos-phorylcholine (GFC) treatment on the acetylcholine synthesizing and degradating enzymes choline acetyltransferase (ChAT) and acetylcholinesterase
(AChE) and on cholinergic muscarinic M-1 and M-2 receptors were assessed in the hippocampus using immunocytochemical, histochemical and radioligand binding techniques, respectively.
The aqueous extract strongly inhibited acetylcholinesterase
(AchE) in an in vitro microassay, an effect ascribable mainly to serpentine ([IC.
Itopride is a dopamine D2 antagonist that inhibits acetylcholinesterase
Another study suggests that CPF might have an effect on head circumference related to the activity of paraoxonase (PON1), an enzyme that can detoxify CPF before it can inhibit acetylcholinesterase
(Berkowitz et al.
inhibitor, manufactured under the name Reminyl by Johnson & Johnson, has been linked to 15 deaths (1.
Aricept (donepezil) inhibits acetylcholinesterase
only; Cognex (tacrine) also inhibits butyrylcholinesterase but is no longer prescribed because it causes liver toxicity, said Dr.
Phenserine, to which AXONYX holds worldwide rights, is a potent, brain targeted, reversible and highly selective inhibitor of the enzyme, acetylcholinesterase