Prebiotic origin of glycolytic metabolism: histidine and cysteine can produce acetyl CoA
from glucose via reactions homologous to non-phosphorylated Entner-Doudoroff pathway.
The retro inhibition of this enzyme may cause the lesser utilization of acetyl CoA
, which in turn is a breakdown product of triglycerides.
Acetylation of histones and non histone proteins contributes predominantly to this regulation by altering the chromatin structure and protein activity using acetyl CoA
as the donor molecule.
These include acetyl CoA
carboxylase, the rate limiting enzyme that initiates fatty acid synthesis.
One possible hint is that the statins block an early step in the enzymatic pathway that eventually turns acetyl CoA
into cholesterol, while the nitrogen-containing bisphosphonates--alendronate and risedronate--block a step that occurs later in this pathway.
Molecular cloning of two different cDNAs for maize acetyl CoA
This led to the suggestion that hyperinsulinaemia and insulin resistance due to impaired insulin action and/or insulin receptor activity and binding might lead to a reduction in glucose utilization and glycolytic enzymes and subsequent decrease in acetyl CoA
and acetyl choline synthesis .
that show that the company has identified a series of novel, highly potent, and highly selective Acetyl CoA
Carboxylase (ACC)1/2 allosteric inhibitors.