The retro inhibition of this enzyme may cause the lesser utilization of acetyl CoA
, which in turn is a breakdown product of triglycerides.
Acetylation of histones and non histone proteins contributes predominantly to this regulation by altering the chromatin structure and protein activity using acetyl CoA
as the donor molecule.
These include acetyl CoA
carboxylase, the rate limiting enzyme that initiates fatty acid synthesis.
One possible hint is that the statins block an early step in the enzymatic pathway that eventually turns acetyl CoA
into cholesterol, while the nitrogen-containing bisphosphonates--alendronate and risedronate--block a step that occurs later in this pathway.
that show that the company has identified a series of novel, highly potent, and highly selective Acetyl CoA
Carboxylase (ACC)1/2 allosteric inhibitors.