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In the presence of ConA, in vitro T-cell activation requires accessory cells for co-stimulatory signals (Pollard and Landberg 2001).
The Role of Accessory Cells in Tumor Angiogenesis (Takakura)
Negative depletion techniques such as the Eligix(TM) BCell HDM Separation System have been shown to specifically purge CD19 and CD20 cells while retaining both stem cells and other accessory cells in the product.
Furthermore, effector functions are tried to be increased via antigen-dependent cellular cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC) or increased recruitment of T cells and accessory cells.
This simultaneous binding subsequently results in the costimulation and activation of T-cells and accessory cells, enabling the generation of a strong immune response against tumor cells.