None of the cases with acantholysis
mimicking pemphigus, such as Grover disease and staphylococcal scalded skin syndrome, exhibited IgG4 immunoreactivity.
Chernyavsky Al, Arredondo J, Piser T, Karlsson E, Grando SA: Differential coupling of M1 muscarinic and alpha7 nicotinic receptors to inhibition of pemphigus acantholysis
The diagnosis of Hailey-Hailey disease can be confirmed with a biopsy of perilesional skin that shows large numbers of keratinocytes in the suprabasal epidermis with incomplete acantholysis
was focally found within the epithelium of a portion of the infundibulum of the central cystic structure (Fig.
Lanza A, Cirillo N, Femiano F, Gombos F: How does acantholysis
occur in pemphigus vulgaris: a critical review.
Immunopathological mechanisms of acantholysis
in pemphigus vulgaris: an explanation by ultrastructural observations.
2) They are histologically characterized by suprabasilar acantholysis
and immunopathologically characterized by autoantibodies to desmosomal cadherins.
Key Words: Autoimmune bullous disease, acantholysis
, pemphigus, bullous pemphigod, subepidermal bullous disease
In addition, the term transient acantholytic dermatosis is misleading, considering Grover disease can, in fact, be persistent and show morphologies other than acantholysis
Although the tumor showed a large spindle cell component, it also has significant areas of acantholysis
and pseudoglandular and pseudovascular spaces.
Endolymphatic invasion was observed in 7 cases, acantholysis
of tumor cells in 10 cases, squamous whorls in 15 cases, and hyalinized stroma was evident in 7 cases.