thalassemia

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Related to a-thalassemia: Alpha Thalassemia, Thalassaemia minor
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Most a-thalassemia mutations involve deletions of one (-[alpha]) or both (- -) [alpha]-globin genes, whereas point mutations within the [alpha]-globin genes ([[alpha].
In addition, the frequently occurring concomitant a-thalassemia also modifies disease activity.
It occurs at higher percentages in cord blood of newborns with a-thalassemia because of the self-assembly of the accumulating unpaired [gamma] chains.