To reach the conclusion, Deasy and her team analyzed sections of two-foot-long human umbilical cords that were donated for research, looking for cells in Wharton's jelly
and blood vessel walls that displayed the characteristic protein markers found in stem cells derived from other sources.
Davies said that while scientists first suggested in 1991 that Wharton's Jelly
might contain precursor cells, no one really knew where to look.
Among the findings: Wharton's jelly
cells from pigs were propagated in the lab for more than a year without losing potency; they can be stored cryogenically; and engineered to express foreign proteins.
Our results show that Wharton's jelly
cells are easily attainable and can be expanded in vitro, maintained in culture, and induced to differentiate into neural cells," the report states.
The umbilical cord was focally deficient of Wharton's jelly
and showed stricture and mild torsion adjacent to the abdominal insertion site.
Umbilical tested cord structure Histologic parameter (%) (N = 9) Umbilical artery(a) Acute inflammation 3/8 (38) Chronic inflammation 3/8 (38) Necrosis 2/8 (25) Normal 3/8 (38) Umbilical vein Acute inflammation 7/9 (78) Chronic inflammation 5/9 (56) Necrosis 5/9 (56) Normal 1/9 (11) Wharton's jelly
Acute inflammation 8/9 (89) Chronic inflammation 5/9 (56) Normal 1/9 (11) Specimens without treponemes Odds ratio Umbilical No.
La Jolla, CA) has patented methods for isolating and using prechondrocytes from the umbilical cord, specifically from Wharton's jelly
, that give rise to chondrocytes which produce cartilage.
AuxoCell's primary research focus is to develop the enormous therapeutic potential of the primitive stem cells found in the Wharton's Jelly
of the human umbilical cord.