In addition to this mega-competitor challenge, Merck also faces a cluster of major patent expirations during the next three years, including Vasotec
, Pepcid, Prilosec, Mevacor, and Prinivil.
Its top products are well-known to anyone who has spent time waiting in line at a pharmacy: Propecia, Maxalt, Vioxx, Zocor and Vasotec
, among others.
For example, Merck has challenged Apotex in Canada over Vasotec
, Canada's largest selling medicine and Merck's top product.
ACE (angiotensin-converting enzyme) inhibitors, including Capoten, Vasotec
, Prinivil, and Zestril, cause blood vessels to dilate.
Merck's cardio-vascular drug, Vasotec
, has generated over one billion dollars in sales in its first two years on the market.
Much of Merck's rapid growth was due to Vasotec
, a heart drug introduced in 1986 that now commands over US $ 1 billion a year in sales, and an assortment of other medications for heart disease.
Barzoukas' representations in Hatch-Waxman Act patent infringement suits have resulted in the protection of the franchises for major pharmaceutical products, such as FOSAMAX, FOSAMAX OW, VASOTEC
, PEPCID, ACTONEL, SINGULAIR, TEMODAR and VIOXX.
Commonly used ACE inhibitors include Vasotec
, Captopril, Zestril, Accupril, Lotensin.
Drug FFS Mentions Drug HMO Mentions Lanoxin 11,040,029 FUROSEMIDE 765,020 Cardizem 7,279,562 Lanoxin 738,471 Procardia 6,848,458 Vasotec
580,145 Zantac 6,775,104 Cardizem 545,495 FUROSEMIDE 6,190,546 HCTZ(**) 496,224 Lasix 6,000,161 Procardia 479,228 Vasotec
5,992,800 Premarin 413,688 Synthroid 5,697,207 Synthroid 402,307 Capoten 5,500,437 ISOSORBIDE DN 401,875 Premarin 5,131,864 Ventolin 386,878
Two products, Mevacor and Vasotec
, are megadrugs with sales topping $1 billion.