8 July 2013 - Study findings have shown that the analysis of three biomarkers in the urine of kidney transplant recipients can diagnose and even predict transplant rejection
, the US National Institute of Allergy and Infectious Diseases (NIAID), which sponsored the clinical trial, said last week.
Viron added that its lead therapeutic candidate, VT-111, has demonstrated potent effects in preclinical suppression of chronic organ transplant rejection
and, in a Phase IIa clinical trial of 48 patients, demonstrated reduced cardiac tissue damage in patients with ACS receiving cardiac stent implants.
Cylex says a statistically significant correlation was reported between high pre-transplant levels of cellular immune response, as measured using ImmuKnow immune cell function test, and early acute transplant rejection
as well as unstable kidney function within the first 90 days following kidney transplantation.
a San Francisco-based molecular diagnostics company focused on non-invasive gene expression-based tests for the monitoring of organ transplant rejection
and autoimmune diseases, announced today that it has established a $12.
Perhaps most importantly, this advance will allow doctors to provide highly personalized care that could prevent transplant rejection
We are proud to have the use of the AlloMap test described in the recommendations for the non-invasive monitoring of acute heart transplant rejection
in these unprecedented evidence based practice guidelines.
Researchers looked at AlloMapT molecular expression testing, a gene expression test which provides information about 20 genes representing molecular pathways in white blood cells found to be associated with heart transplant rejection
, as well as information about control genes.
One group, led by Benedict Cosimi at Massachusetts General Hospital in Boston, tried ICAM-1 antibodies as a treatment for kidney transplant rejection
, "but the [efficacy] results were not so great," Isobe says.
Life Science Analytics' Transplant Rejection
and Transplantation Therapy Area Pipeline Report contains detailed information on the Transplant Rejection
and Transplantation drug pipeline.
The company reports it sponsored an open label investigational clinical trial in Moscow, Russia last year at the Central Clinical Research Institute of Eyes, which successfully halted corneal transplant rejection
in all 13 patients by using the investigational antibodies as a topical treatment in the form of eye drops.
For example, IL-1 causes much of the swelling and cartilage damage seen in rheumatoid arthritis and plays a key role in organ transplant rejection
Life Science Analytics, Transplant Rejection
or Transplantation Therapy Area Pipeline Report contains detailed information on the transplant rejection
or transplantation drug pipeline.
Atlanta, GA announced it has begun a Phase I clinical trial of AGI-1096 as an oral treatment for the prevention of organ transplant rejection
The companies say the initial results of the clinical trials serve to support the safety and effectiveness of Apomate in imaging apoptosis, or programmed cell death, in the noninvasive detection of cardiac transplant rejection
, which now requires invasive catheterization procedures.
Hailed as a breakthrough in organ transplantation, the drug cyclosporine suppresses the immune system, reducing the chances of transplant rejection