In cases of catheter related blood stream infections where systemic antibiotic
treatment fails and catheter removal is impossible, antibiotic lock therapy may be a therapeutic option.
reported the case of a patient with type 2 diabetes mellitus who had a KLA and bacteremia; after administration of systemic antibiotics
and adequate drainage, the patient developed a K.
Although the economic analysis by Flemming and Beikler assessed the administration of both local and systemic antibiotics
, that discussion falls outside of the purview of this paper.
Prophylactic use of systemic antibiotics
, many of which have been used either alone or in combination, has resulted in a significant reduction in wound infection rate3.
Guided by the PICO question, the keywords used in various combinations were AOM, systemic antibiotic
use, and topical treatments.
In conclusion, massive, and perhaps unjustified, systemic antibiotic
use in communities, particularly those involving close interaction between members, may permit the emergence of multiresistant bacteria such as MRSA, with a high risk for disease.
The formulations are to be used for chronic maintenance therapy as they are expected to achieve higher antibiotic concentration at the site of infection and relatively low systemic antibiotic
concentrations to minimize side-effects.
Adjunctive systemic antibiotic
therapy is more effective when administered with initial nonsurgical periodontal therapy than when administered at reevaluation.
6,7) However, for generalized chronic (formerly adult) periodontitis, systemic antibiotic
therapy has demonstrated little clinical efficacy.
Because of the potential for exacerbating the resistance problem, systemic antibiotic
therapy is reserved for patients with active systemic infections.
The results of this multicenter prospective randomized double-blind placebo-controlled trial, taken together with those of another recent large study, "call into question the perception--largely based on expert opinion or smaller, underpowered, and lower-quality noninferiority trials--that cure rates do not improve with the addition of systemic antibiotic
treatment after incision and drainage," said Robert S.
Microbial species associated with various forms of periodontitis are also outlined, and the author makes evidence-based recommendations for systemic antibiotic
therapy for diagnoses based on either microbial testing or clinical assessments.
The diagnosis was based on three criteria: (1) a severe, painful inflammation of the external auditory canal accompanied by exudate, edema, and granulation tissue; (2) a protracted course of at least 3 weeks during which time the patient did not respond to topical and/or systemic antibiotic
therapy; and (3) evidence of bony erosion on computed tomography (CT) of the temporal bone or a positive finding on technetium-99m ([sup.
I've tried to trace where the prejudice comes from, and I haven't been able to determine it," he said, adding that he believes many physicians, presented with evidence of equal efficacy, would prefer to use a topical medication rather than expose their patients to a systemic antibiotic
Limit systemic antibiotic
use to the shortest possible duration, typically 3 months.