Delayed density-dependent prevalence of Sin Nombre virus
infection in deer mice (Peromyscus maniculatus) in central and western Montana.
16) The investigators concluded the dramatic increase in high-desert rainfall associated with the 1992-1993 El Nino weather pattern contributed to the risks of Sin nombre virus
exposure in the region and that annual precipitation predictions would be of value in designing disease prevention campaigns.
Role of maternal antibody in natural infection of Peromyscus maniculatus with Sin Nombre virus
A RIBA has been developed to detect antibodies to Sin Nombre virus
Sin Nombre virus
in deer mice captured inside homes, southwestern Montana.
Mild hantaviral disease caused by sin Nombre virus
in a fouryear-old child.
We used ELISAs to test the samples for IgG with the specific antigen for Sin Nombre virus
and for IgM with the Laguna Negra and Andes viruses.
Genetic links of the type have been reported for PUUV infections in Finland (11) and for Sin Nombre virus
infection during the outbreak in the Four Corners area of the United States (4,12), but perfect sequence match was not observed.
The most frequently recognized etiologic agent of HPS in North America, Sin Nombre virus
(SNV), is transmitted to humans from its primary rodent reservoir, Peromyscus maniculatus (deer mousel), by direct contact with infected rodents, rodent droppings, or nests or through inhalation of aerosolized virus particles from mouse urine and feces.
Virus culture and identification was attempted in African green monkey Vero cell cultures by indirect immunofluorescence assay and Sin Nombre virus
(SNV) polyclonal antibodies, as described for arboviruses (22).
This report describes the investigation of two cases of Sin Nombre virus
(SNV)-associated HPS involving feedlot workers in a single household during May-June 1995, and summarizes national reporting for HPS through March 21, 1996.
The viruses known to cause HPS on the North American continent are Bayou virus, Black Creek Canal virus (BCCV), Choclo virus (CHOV), New York virus, and Sin Nombre virus
Subsequent retesting of these samples, as well as of an additional sample obtained in September 1994, with Sin Nombre virus
(SNV) antigens confirmed the diagnosis of HPS.
In binding assays, antibody to all known hantaviruses indigenous to the Americas cross-react with the N protein of Sin Nombre virus
Hantavirus pulmonary syndrome (HPS) was first recognized in 1993 after an outbreak of acute respiratory distress syndrome associated with Sin Nombre virus
occurred in the southwestern United States (1).