Sin Nombre virus
and rodent species diversity: a test of the dilution and amplification hypotheses.
Delayed density-dependent prevalence of Sin Nombre virus
antibody in Montana deer mice (Peromyscus maniculatus) and implications for human disease risk.
Rapid and specific detection of Sin Nombre virus
antibodies in patients with hantavirus pulmonary syndrome by a strip immunoblot assay suitable for field diagnosis.
Hantavirus pulmonary syndrome (HPS) was first recognized in 1993 after an outbreak of acute respiratory distress syndrome associated with Sin Nombre virus
occurred in the southwestern United States (1).
In the United States, most HPS cases are likely caused by Sin Nombre virus
(6), the virus responsible for the initially identified HPS cases.
The respiratory form of the disease was described in June 1993 during an epidemic of severe respiratory disease caused by Sin Nombre virus
in the United States (3).
These samples were tested by IgM capture with inactivated Sin Nombre virus
antigens and by indirect ELISA with recombinant antigens to detect IgG antibodies to Sin Nombre virus
In North America, Sin Nombre virus
(SNV) is responsible for most cases of HCPS, and the deer mouse (Peromyscus maniculatus) is its main reservoir.
Most of the 506 confirmed cases in the United States have been caused by Sin Nombre virus
Longitudinal studies of Sin Nombre virus
in deer mouse-dominated ecosystems of Montana.