was dissolved in CS and lactic acid solution.
The gel, which contains 30 times less silver than silver sulfadiazine
, did not have any apparent toxic effects when applied to the healthy skin of test animals.
A multicentre, randomised control trial compared this catheter with the ARROWgard[TM] (chlorhexidine/ silver sulfadiazine
impregnated catheter) in adult patients (27).
Localized argyria is caused by local exposure to silver, for example by silver jewelry or silver sulfadiazine
Another method used experimentally is the topical application of methylene blue (150 g) mixed with silver sulfadiazine
Topical preparations that may be helpful include dimethyl sulfoxide (Rimso-50), silver sulfadiazine
(Silvadene), benzoyl peroxide (Benzac, Brevoxyl, Desquam, Triaz, ZoDerm), oxyquinoline (Trimo-san Vaginal Jelly), and gentamicin (Garamycin).
During the 1960s, silver nitrate and silver sulfadiazine
cream were employed as antimicrobial agents in the treatment of wound infections.
At Nebraska Medical Center, patients often are treated topically with silver sulfadiazine
16) and silver sulfadiazine
as a topical chemoprophylaxis agent for burns.
Cutaneous burns, when they do occur should be treated as thermal cutaneous burns with bacitracin, silver sulfadiazine
or mafenide acetate.
inhibits epithelial migration and can delay healing.
Silver nitrate drops may be used on newborns to prevent eye infections; silver sulfadiazine
cream is used topically to prevent and treat infection in second- and third-degree burns.
However, in vitro studies of Pseudomonas stutzeri exposed to slowly increasing concentrations of chlorhexidine, in the absence of silver sulfadiazine
, have demonstrated the development of resistance to chlorhexidine and associated resistance to several classes of therapeutic antimicrobial agents (17).
Topicals such as silver sulfadiazine
penetrate the eschar in order to provide this effect but are continuously absorbed and may lead to adverse reactions (Lynch, Key, & White, 1979).
has been widely accepted as the standard treatment for burn injuries in both animals and humans [1, 2].