In these conditions microglia can produce ROS, NO, and proteolytic enzyme, enhancing the senile plaques
and NFTs formation .
Studies revealed that 25kDa protein fraction is a normal plasma constituent that is observed in senile plaques
and neurofibrillary tangles in brains of Alzheimer's disease (AD) patients and its level in the AD group is significantly lower than that of the control group (Nishiyama, 1996).
Since many of the above-described findings can occur in non-demented elderly patients, an accurate pathologic diagnosis of AD requires information regarding the age and clinical history of the patient as well as an evaluation of the number and distribution of senile plaques
and neurofibrillary tangles.
Today, he says, it's most likely that there are two primary causes of dementia: an Alzheimer's disease type "pathology," represented by the neurofibrillary tangles and senile plaques
of the disease, and vascular dementia, resulting from significant changes in blood vessels in the brain.
The LI-COR Odyssey(R) Infrared Imaging System is being used as a detection platform for non-invasive screening of senile plaques
Clumps of large, sticky proteins forming senile plaques
have been observed in the brains of people with Alzheimer disease ever since neurologist Alois Alzheimer first described the disorder nearly a century ago.
The clinical diagnosis of AD can be confirmed only through postmortem examination of senile plaques
and neurofibrillary tangles in the brain--much like the assessment Alois Alzheimer performed nearly 100 years ago.
Another program targets spherons, tiny balls of proteins found in the human brain, which Nymox researchers believe are a major source of senile plaques
, a hallmark of the disease.
TORONTO -- The [beta]-amyloid senile plaques
and neurofibrillary tangles that are definitive for a diagnosis of Alzheimer's disease can now be identified without the need for brain biopsy specimen.
The PET image shows high densities of [beta]-amyloid senile plaques
and neurofibrillary tangles in the hippocampal region.
HLA-DR immunostains showed microglia in the senile plaques
of 3 DS patients.
Although senile plaques
represent a defining hallmark of Alzheimer's disease (AD) brains their role in disease pathophysiology remains unclear.
The computer, which fills the space of two basketball courts, will be put to many uses, one of which is to analyze the formation of senile plaques
in the brains of patients with Alzheimer's disease.
13] Alzheimer's disease is a progressive and degenerative disease of the brain, causing the loss of millions of nerve cells and the appearance of senile plaques
on the brain.
The major chemical component of senile plaques
in the brains of Alzheimer's disease patients has been identified as a protein called beta-amyloid, which is not normally found in brain tissue.