A prospective case-control study analyzes 12 thrombophilic gene mutations in Turkish couples with recurrent pregnancy loss
Kolte expressed frustration at providing the best care for these patients, observing that there is a severe lack of understanding of the pathophysiology of recurrent pregnancy loss
and no evidence-based treatment for the majority of RPL patients.
Definitions of infertility and recurrent pregnancy loss
Earliest treatment for recurrent pregnancy loss
associated with aPL was a combination of high dose prednisone and low-dose aspirin, with successful outcome in 75% of treated pregnancies.
Elevated blood flow resistance in uterine arteries of women with unexplained recurrent pregnancy loss
Jamie Massie, examined the live birth rate by embryonic karyotype among 95 women with a self-reported history of recurrent pregnancy loss
Conversely, the women suffering from recurrent pregnancy loss
had low levels of SGK1.
of Chicago Recurrent Pregnancy Loss
Program) compile 26 chapters that take a multidisciplinary approach to problems in early pregnancy.
The reports of histomorphological changes in placenta in women with recurrent pregnancy loss
in association with thrombophilia are relatively recent (14-30) and all of them broadly show non vascularisation of villi, multiple vessel thrombosis, infarction, fibrosis and decidual vasculopathy.
Standard treatment of recurrent pregnancy loss
associated with aPL is low-dose aspirin and a prophylactic dose of subcutaneous heparin.
Several studies also demonstrated that high tHcy is a risk factor of placenta-mediated diseases, such as preeclampsia, spontaneous abortion, placental abruption, and recurrent pregnancy loss
Lockwood is an internationally known obstetrician-gynecologist and scientist whose research interests include the prevention of recurrent pregnancy loss
and preterm delivery.
Not only is the septate uterus the most common Mullerian anomaly, it is the uterine malformation associated with the poorest reproductive outcomes, including recurrent pregnancy loss
, preterm labor, malpresentation, and probably infertility.
Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss
Inherited and acquired thrombophilia can be found in more than 50% of women suffering from recurrent pregnancy loss
of unknown cause (1).