High prevalence of activating RET proto-oncogene
rearrangements in thyroid tumors from patients who had received external radiation.
Activating point mutations in RET proto-oncogene
and germline mutations in RAS are implicated in the pathogenesis of MTC.
Takahashi, "cDNA cloning of mouse ret proto-oncogene
and its sequence similarity to the cadherin superfamily," Oncogene, vol.
testing has been shown to be vastly superior to measurement of calcitonin levels in identifying preclinical MTC cases, with a specificity approaching 95--100%.
A positive RET proto-oncogene
in codon 918 was confirmatory.
Mutations of the RET proto-oncogene
causative for MEN 2 were identified in 1993.
Included in the Practice Guidelines are an overview of pre-analytic factors, a discussion of the importance of the laboratory-physician interface, and a detailed look at the range of thyroid tests available, including measurement of total and free thyroxine (T4) and triiodothyronine (T3), thyroid stimulating hormone, thyroid autoantibodies (thyroid peroxidase, thyroglobulin, and thyrotrophin receptor antibodies), thyroglobulin, calcitonin, the ret proto-oncogene
, and urinary iodide.
(RET) is an RTK gene located on 10q11.
Molecular studies showed a point mutation in amino acid 918 in exon 16 of the RET proto-oncogene
76) In our practice, thyroid lobes in patients with germline mutation in the RET proto-oncogene
that are grossly unremarkable are serially sectioned at 2 to 3 mm and submitted entirely for microscopic examination.
Diagnosis of multiple endocrine neoplasia [MEN] 2A, 2B and familial medullary thyroid cancer [FMTC] by multiplex PCR and heteroduplex analyses of RET proto-oncogene
A number of specific gene mutations have been identified in thyroid cancers, including point mutations of B-Raf proto-oncogene, serine/threonine kinase (BRAF) and RAS viral (r-ras) oncogne homolog (RAS), and gene rearrangements of ret proto-oncogene
(RET/PTC) and paired box 8/ peroxisome proliferator activated receptor G (PAX8/PPARG).
Abbreviations: ALK, anaplastic lymphoma receptor tyrosine kinase (anaplastic lymphoma kinase);BRAF, v-raf murine sarcoma viral oncogene homolog B; EGFR, epidermal growth factor receptor;EML4, echinoderm microtubule-associated protein-like 4; HER2-ERBB2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (human epidermal growth factor receptor 2);K-T, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;KRAS, Kirsten rat sarcoma viral oncogene homolog;MMR, mismatch repair protein;MSI, microsatellite instability; RET, RET proto-oncogene
The RET proto-oncogene
in multiple endocrine neoplasia type 2 and Hirschsprung's disease.
Whole-transcriptome sequencing studies performed by Kohno et al reported a novel fusion between KIF5B (the kinesin family 5B gene) and the ret proto-oncogene
(RET), leading to an activation of RET kinase in lung adenocarcinomas.