In a new study, researchers at Boston Children's Hospital used stem cell technology to create cerebellar cells known as Purkinje cells
from patients with tuberous sclerosis complex (TSC), a genetic syndrome that often includes ASD-like features.
Conclusion: It was concluded from current results that radiations from 2G, 3G and 4G mobile phones have deleterious effects on the organization of Purkinje cell
layer of cerebellum with 3G and 4G causing more harm as compared to EMF from 2G mobile phones.
The late onset of severe ataxia and loss of cerebellar Purkinje cells
in several [Prnp.
All three trimester binge alcohol exposure causes fetal cerebellar purkinje cell
loss in the presence of maternal hypercapnea, acidemia, and normoxemia: Ovine model.
Cell counts were made by measuring a line in the monolayer of Purkinje cell
, and an index was obtained considering number of Purkinje cells
per lineal extent ([micro]m).
In the NE rats the mean volume of Purkinje cell
soma was 15% smaller than those of the control rats (table 2).
Only 20% showed nervous signs and brain lesions of neuronal and Purkinje cell
necrosis of cerebrum and cerebellum, respectively.
Although zinc supplementation in one study did not mitigate alcohol-induced cerebellar Purkinje cell
loss following developmental alcohol exposure (Chen et al.
Effect of prenatal exposure to diclofenac sodium on Purkinje cell
numbers in rat cerebellum: A stereological study.
Another interesting pattern in the cerebellum was seen for MABs 12C4 (J), 12D11 (K), and 7E6 (L), wherein the wide, sinusoidal-shaped area containing the Purkinje cell
layer was particularly obvious because of the lack of any reaction product.
MAPPING THE PURKINJE CELL
DEGENERATION (PCD) LOCUS IN MUTANT MICE.
Variations in the human Purkinje cell
population according to age and sex.
At P5 and P7, Calbindin immunostaining showed formation of the Purkinje cell
layer with extension of the dendrites and axons (Fig.
For example, Purkinje cell
apoptosis is enhanced in utero during fetal alcohol syndrome .
The cerebellar folia also had widespread lesions, with a predilection for Purkinje cell
necrosis and loss, with characteristic Bergmann glial and microglial proliferation and dendritic spheroids in the overlying layer; however, axonal torpedoes were rarely found (Figure 4).