Concurrent with the Phase II clinical trial, punctal plug
prototype designs for the sustained delivery system are being tested in an ongoing multicenter study in more than 500 healthy volunteers.
Announced interim data from an ongoing Phase II clinical trial and a device study for the punctal plug
Keywords: dry eye syndrome, symptoms, punctal plugs
, lasik, rose bengal
Until recently, there were just two treatments for dry eyes: over-the-counter artificial tear eye drops designed to replace your natural tears, or a non-surgical procedure called punctal plugs
in which tiny bits of silicon are inserted into the openings on the lower and upper lids where tears drain into the nose.
It can be fairly said that EySite-NanoM(TM) utilizes a sustained release delivery systems for front-of-the-eye ocular delivery with the dosing advantages of punctal plugs
and drug-coated contact lenses, without the disadvantages.
More severe cases can be managed with punctal plugs
(see Figure 3) and if this is not sufficient, surgical treatment to reduce ocular exposure can be effective.
that block tear drainage channels can help conserve tears for dry eye suffers who get no relief from artificial tears.
are a simple and effective solution to treat dry eyes that have not responded to simple measures described above.
Current therapies: Allergan/Inspire Pharmaceuticals' Restasis, Eisai/Kissei Pharmaceutical's Salagen, Daiichi Sankyo's Evoxac, punctal plugs
, hydroxychloroquine, methotrexate, azathioprine
Contact lenses and punctal plugs
are used to deliver drugs to the anterior segment of the eye while intravitreal implants and injectable particulate systems are used for drug delivery into the posterior segment of the eye.