Domain specificity of the human antibody response to Bacillus anthracis protective antigen
This new capsule vaccine is expected to work against possible vaccine-resistant strains of anthrax and to protect individuals who may not respond optimally to protective antigen
A way in Anthrax toxin from the Bacillus anthracis bacterium is composed of three proteins, called protective antigen
, edema factor and lethal factor.
Valortim is a monoclonal antibody, which binds to certain varieties of protective antigen
and keeps it fro linking up with others to make the toxic combination that kills.
Monitoring of ELISA-reactive antibodies against anthrax protective antigen
(PA), lethal factor (LF), and toxin-neutralising antibodies in serum of individuals vaccinated against anthrax with the PA-based UK anthrax vaccine.
This could be due to its putative mechanism of action compared to other monoclonal candidates under development - binding to protective antigen
and inhibiting heptamer (spore) formation, rather than inhibiting binding of toxin to its receptor.
The sequence of 4D8 was shown to be conserved among different tick genera and the activity of subolesin protective antigen
was demonstrated to extend to other tick species, including non-Ixodes tick species (39).
Anthim is a high-affinity monoclonal antibody, targeting the anthrax toxin Protective Antigen
Response After Receiving Two Doses of TIV Percentage of subjects with Antigen/ protective antibody response baseline serostatus After dose 1 After dose 2 A/H1N1 Seronegative 35 5 Seropositive 85 100 A/H3N2 Seronegative 11 88 Seropositive 100 100 B/Jilin Seronegative 17 48 Seropositive 100 100 Note: Based on a study of 222 children aged 5-8 years.
The United States Department of Health and Human Services (Washington, DC) has patented a vaccine for inducing an immune response in mammal to a specific antigen, where the vaccine comprises a unit dose of a binary toxin protective antigen
and the antigen, which is bound to a binary toxin protective antigen
The microbe's toxin is made up of three key parts: edema factor (EF), lethal factor (LF), and protective antigen
anthracis protective antigen
(PA) by enzyme-linked immunosorbent assay (4).
After a single dose 50% of the volunteers had high levels of immune responses against a known protective antigen
of Etec, rising to 70% after two doses.
After a single dose 50 per cent of the volunteers had high levels of immune responses against a known protective antigen
of ETEC, rising to 70 per cent after two doses.
Plasmid X01 carries the three toxin genes coding for edema factor, lethal factor and protective antigen