Hyperkalemia is also a possible side effect, especially for patients diagnosed with diabetes or renal impairment, or taking ACE inhibitors in combination with potassium-sparing diuretics
(Adams et al.
Spironolactone HCl is a synthetic 17-lactone drug that is a renal competitive aldosterone antagonist in the class of pharmaceuticals known as potassium-sparing diuretics
When using potassium-sparing diuretics
, avoid eating large amounts of potassium-rich foods such as bananas, oranges, and green leafy vegetables, or salt substitutes that contain potassium.
Also at risk is anyone on a medication that causes the body to hold onto potassium, including potassium-sparing diuretics
like Dyazide and Spirozide, ACE inhibitors like Lotensin and Vasotec, angiotensin-receptor blockers such as Tevetan and Avapro and daily doses of nonsteroidal anti-inflammatory drugs like aspirin and ibuprofen.
Types of diuretics include thiazides, such as Diuril (chlorothiazide) and Esidrex (hydrochlorothiazide); potassium-sparing diuretics
, such as Aldactone (spironolactone); and loop diuretics, such as Lasix (furosemide).
A large study, reported in the May 2006 Archives of Neurology, found that use of potassium-sparing diuretics
to control hypertension resulted in lowering Alzheimer's risk by more than 70 percent.
Differing effects of mineralocorticoid receptor-dependent and-independent potassium-sparing diuretics
on fibrinolytic balance.
Elderly patients who took potassium-sparing diuretics
had a 70% lower rate of developing Alzheimer's disease than those who did not take antihypertensive drugs in a population-based study of dementing illnesses, reported Ara S.
It should be used with caution in women on other medications that can increase potassium, including NSAIDs, potassium-sparing diuretics
, ACE inhibitors, or angiotensin II receptor antagonists.
obviously may spare potassium and magnesium.
Persons taking frusemide and the potassium-sparing diuretics
had higher creatinine levels than those taking thiazides.
That's why potassium-sparing diuretics
are sometimes prescribed to help maintain healthy levels.
Furthermore, nephrology nurses should conduct a medication review to assess whether the patient is on medications that may contribute to hyperkalemia, such as ACE Inhibitors, angiotensin II receptor blockers, potassium-sparing diuretics
, or medications that may contribute to hypokalemia, such as fludrocortisone, furosemide, or sodium polystyrene sulfonate.
However, some salt substitutes are composed of potassium chloride (instead of sodium chloride, which is found in regular salt), and extra potassium can be problematic for people who have kidney problems or those taking certain medications, such as potassium-sparing diuretics
and other common blood pressure medications.
b) The beneficial effect on urinary excretion may be similar to action of potassium-sparing diuretics
due to unchanged potassium levels in the Se-SM group