Antihypertensive agents in general reduced the risk for Alzheimer's disease (AD), but the potassium-sparing diuretics
were particularly beneficial, said Dr.
, potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
b) The beneficial effect on urinary excretion may be similar to action of potassium-sparing diuretics
due to unchanged potassium levels in the Se-SM group
Decrease potassium replacement if serum potassium is raised or decrease/stop potassium-sparing diuretics
Patients with moderate renal impairment who are taking medications that interfere with potassium excretion, such as potassium-sparing diuretics
, or medications that interfere with the renin-angiotensin-aldosterone system are more likely to develop hyperkalemia.
Caution should be exercised when using these therapies in patients with severe CKD concomitantly using one or a combination of the following medications: ARBs, non-steroidal anti-inflammatory agents (NSAIDs), potassium supplements, and potassium-sparing diuretics
When broken down further by subtypes of antihypertensive agents, the potassium-sparing diuretics
had the most significant protective effect, with a 73% reduction in risk for Alzheimer's disease.
Also contraindicated in people on potassium supplements, potassium-sparing diuretics
(amiloride, spironolactone, or triamterene), and drugs that are strong inhibitors of CYP450 3A4, such as ketoconazole or itraconazole.
May experience synergistic effects on potassium elevation with the use of ACE inhibitors, cyclosporine, tacrolimus, and other potassium-sparing diuretics
Fifty-four subjects (mean age, 74 years) had physician-diagnosed hypertension for which they took beta-blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, potassium-sparing diuretics
, alpha-blockers, or a combination of these drugs.
As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics
, potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium.