May experience synergistic effects on potassium elevation with the use of ACE inhibitors, cyclosporine, tacrolimus, and other potassium-sparing diuretics
And the 523 patients on ACE inhibitors who were admitted for hyperkalemia were about 27 times more likely to have been treated with a potassium-sparing diuretic
in the past week, compared with controls (adjusted odds ratio, 20.
5-25 mg of hydrochlorothiazide daffy) and adding a potassium-sparing diuretic
drug when higher diuretic doses are needed.
The use of potassium-sparing diuretics
may not eliminate the need for potassium supplementation, however; in this study, five of the 10 subjects were taking a so-called potassium-sparing diuretic
The data also suggested that rapid progression of heart failure could be aborted in those who aren't taking a potassium-sparing diuretic
by adding one to their drug regimen, the researchers noted.
Because thiazide diuretics increase potassium excretion, they are often used in combination with a potassium-sparing diuretic
to maintain serum potassium at or above 4 mEq/L.
If that's well tolerated, he's willing to consider stopping the patient's potassium-sparing diuretic
or aldosterone, although he generally opts to continue them.
conserve potassium by inhibiting the action of aldosterone.
, such as amiloride, spironolactone (Aldactone), and triamterene (Dyrenium).
If the target BP cannot be achieved with 3 drugs in those classes, other medications such as potassium-sparing diuretics
or beta-blockers can be added.
These drugs include alpha-2 receptor agonists and loop diuretics, potassium-sparing diuretics
, thiazide diuretics, and combination diuretics, Katherine Levandoski said at the annual meeting of the Society for Investigative Dermatology.
such as amiloride have been avoided because of perceived lack of BP-lowering efficacy and increased risk of hyperkalemia because of increasing use of RAS blockers.
There are different types of diuretics, including thiazide, loop and potassium-sparing diuretics
I believe these results will return potassium-sparing diuretics
to prominence," said Dr.
Thiazides are the first-line choice of diuretic (loop and potassium-sparing diuretics
are more likely to be used if you have heart failure), but they may not be suitable for people with impaired kidney function.