In acute toxicity study, the experimental rats had slept several hours, after administration of Passiflora ligularis extract to the Wistar albino rats when compared to normal control rats.
The aqueous fruit extract of Passiflora ligularis was administered orally (200, 400, and 600mg/kg, for 15 days) to experimental animals.
On oral administration of Passiflora ligularis fruit extract to diabetic rats for 30 days significantly reversed these values to near normal.
Table 3 shows the level of hepatic and renal markers; the levels of urea, creatinine, and bilirubin were significantly increased in diabetic group and treatment with Passiflora ligularis extract for 30 days significantly reversed these values to near normal.
Administration of Passiflora ligularis fruit extract decreased the level of liver markers in diabetic treated rats.
On treatment with aqueous fruit extract of Passiflora ligularis and standard drug glibenclamide to diabetic rats for 30 days the values were significantly increased to near normal.
In this study, the liver glycogen level was decreased significantly in Group II diabetic rats, compared to glibenclamide as standard and Passiflora ligularis treated groups.
These enzymatic antioxidants are significantly decreased in different organs (liver, kidney, and pancreas) due to the inadequacy of the antioxidant defences in combating ROS mediated damage and when they are treated with aqueous fruit extract of Passiflora ligularis the activity of these enzymes was increased and may help to control the free radicals when compared to diabetic rats and the effect produced by aqueous fruit extract of Passiflora ligularis was comparable with that of standard drug glibenclamide.
Oral administration of aqueous fruit extract of Passiflora ligularis for 30 days showed significant elevation in all the nonenzymatic antioxidants values and reached near normal values.
The ability of the Passiflora ligularis extracts to quench hydroxyl radicals seems to be directly related to inhibiting the process of lipid peroxidation.