inhibitor

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Related to PDE inhibitor: phosphodiesterase type 5 inhibitors, PDE5
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Antonyms for inhibitor

a substance that retards or stops an activity

References in periodicals archive ?
In an October report in the American Journal of Ophthalmology, Fraunfelder noted that "a well-described mechanism" explaining how PDE inhibitors cause ischemic optic neuropathy "does not exist.
Determine what is new in PDE inhibitor development by review of clinical developments in current pharmaceutical pipelines.
Since IBD in dogs is similar to the disease in humans, these positive preclinical results with a cGMP PDE inhibitor in dogs prompted us to initiate our pilot Phase II study in humans with Crohn's disease.
The SMEs will adopt and progress existing PDE inhibitors that are in different stages of the drug discovery pipeline (i.
With this model for stromal-epithelial signaling, they demonstrated that a) activation of the SHH pathway in the mesenchymal cells stimulated LnCap-C4 cell proliferation and b) treatment with the PDE inhibitors eliminated the SHH-dependent LnCap-C4 cell proliferation.
Researchers then treated the mice with PDE inhibitors, which rescued the sleep deprivation-induced deficits in cAMP signaling, synaptic plasticity and hippocampus dependent memory.
The remaining 14 chapters are concerned with PDEs as pharmacological targets in disease processes and the development of specific PDE inhibitors as therapeutic agents.
NO data are available on the prolonged use of PDE inhibitors in adult critically ill patients, although ample literature is now available on chronically ill subjects with pulmonary hypertension (6).
One area of marked differences in the PDE inhibitors is their selectivity.
Powerful and unexpected synergistic interactions of A2A Agonist and PDE Inhibitors as potential adjunctive therapy in the treatment of multiple myeloma and other B-cell malignancies were published in BLOOD, The Journal of the American Society of Hematology, and highlighted at the American Association for Cancer Research 2010 annual meeting.