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Some studies demonstrated reductions in drug levels of up to 50% with strong CYP3A4 and P-glycoprotein inducers.
Therefore, BDMCur, DMCur and Cur may be the substrates of P-glycoprotein and MRP2; the transport mechanism of BDMCur, DMCur and Cur is the active transport in the carrier-mediated transport.
7,8) These increases are caused by several mechanisms, but the 2 most important may be inhibition of intestinal P-glycoprotein and increases in small intestine absorption surfaces (Table 2).
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein.
To get an idea of how P-glycoprotein works, Cannon said to think of the protein as a hotel doorman, standing in front of a revolving door at a lobby entrance.
The double inhibition of P-glycoprotein using proton pump inhibitor and P-glycoprotein inhibitor caused low P-glycoprotein expression in the cell lines, resulting in higher H.
P-glycoprotein acts as a cell membrane pump and increases the elimination of loperamide from the CNS and systemic circulation.
The most known and studied mode of resistance has been associated with P-glycoprotein (ABCBl/Pgp), the first human ABC transporter to be described.
Polyclonal antibodies against MDR-related protein 1 (MRP1, sc-13960), P-glycoprotein (P-gp, sc-55510), Nrf2 (sc-722), NF-[KAPPA]B-p-65(sc-372), HIF-1[alpha] (sc-10790), PKC[alpha] (sc-208), cMyc (sc-789), glutathione S-transferase-[pi] (GST[pi], ab53943), phosphatase and tensin homolog deleted on chromosome ten (PTEN, sc-7974), PI3K (ab182651), Akt (sc-8312), p-Akt (sc-7985-R) and [beta] -actin (ab8227), and horseradish peroxidase-conjugated (BA1054, BA1050) or FITC-conjugated secondary antibodies (BA1101, BA1105) were purchased from Santa Cruz Biotechnology (sc-, CA, USA), Abcam (ab, MA, USA), and Boster Bio-Engineering Limited Company (BA, Wuhan, China).
The P-glycoprotein efflux pump plays a large role in tacrolimus absorption from the gut and distribution in other tissues, while cytochrome P-450 3A (CYP3A) enzyme is primarily responsible for tacrolimus metabolism [9-11].
Keywords: ATP-binding cassette subfamily B member 1 (ABCB1), Single nucleotide polymorphism, Genotyping, Ondansetron, P-glycoprotein.
AD researchers have discovered that administering a steroid-like chemical to mice bred to develop AD increased the production of a BBB protein called P-glycoprotein that is involved in the elimination from the brain of toxic beta-amyloid proteins.
For example, amiodarone and verapamil, which are used to treat the underlying rhythm disturbance in atrial fibrillation, inhibit intestinal P-glycoprotein so that increased amounts of dabigatran are absorbed (Lehne, 2013).
Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein.