We are delighted the EMA s Committee for Orphan Medicinal Products has considered that avelumab matches the Orphan Drug designation criteria for metastatic Merkel cell carcinoma
in the EU, said Dr.
Recent advances in the understanding of the genetics, etiology, and treatment of Merkel cell carcinoma
Fifty-eight of the 89(65%) Merkel cell carcinoma
patients were vitamin D deficient as defined by a serum level below 50 nmol /L.
They found that patients with Merkel cell carcinoma
who had low numbers of lymphocytes-a type of white blood cell that participates in immune function-didn't live as long after treatment as those with higher lymphocyte counts.
CK20, although negative in most SmCC (pulmonary and extrapulmonary, excluding Merkel cell carcinoma
of the skin), highlights 46% to 73% of bladder UC cases.
Heath M, Jaimes N, Lemos B, et al: Clinical characteristics of Merkel cell carcinoma
at diagnosis in 195 patients: the AEIOU features.
Total spontaneous regression of advanced Merkel cell carcinoma
after biopsy: review and a new case.
Linda Wang for Merkel Cell Carcinoma
Research Fund, 44 Binney Street, Boston Ma 02115.
New topics covered include merkel cell carcinoma
, and dermoscopy.
Merkel cell carcinoma
(MCC) is a highly aggressive disease which develops in the nerve cells that respond to touch.
Pathologic differential diagnosis of clear cell squamous cell carcinoma in situ: conditions with intraepidermal Pagetoid cells Clear cell papulosis Clear cell squamous cell carcinoma in situ Clear cells of Toker (of the nipple epidermis) Extramammary Paget disease Cutaneous T-cell lymphoma Eccrine porocarcinoma Histiocytosis X (Langerhans cell histiocytosis) Langerhans cell microabscess (in cutaneous delayed hypersensitivity reactions) Malignant melanoma in situ (superficial spreading) Merkel cell carcinoma
(with pagetoid intraepidermal spread) Metastasis (epidermotropic) Pagetoid dyskeratosis Paget disease (extramammary and mammary) Sebaceous carcinoma Spitz nevus (pagetoid) Table 2.
Brudnoy, who based his radio show at legendary news-talk station WBZAM, died in Boston on December 9 of the rare skin cancer Merkel cell carcinoma
Neumeier had been undergoing daily radiation treatments for the disease, Merkel cell carcinoma
In addition, there are reports of increased risk of several rare malignancies and proliferative lesions, including Merkel cell carcinoma
, squamous cell carcinoma of the conjunctiva, and multicentric Castleman's disease.
Simon, president of Goodstein Commercial Realty and a prominent member of New York's real estate community, died last week at the age of 69 from merkel cell carcinoma